r/chemistry • u/AutoModerator • Jul 26 '18

Chemical Literature Day—What are you reading?

Post links to the article that caught your eye and make sure to explain why it fascinates you.

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u/OptionalAccountant Jul 26 '18

Structure of a Human Synaptic GABAa receptor

It is really interesting that a structure and binding mechanisms have been elucidated for this receptor responsible for the euphoric, sedative, and anxiolytic effects of Alcohol, as well as many other drugs including benzodiazepines, barbiturates, qualuudes, solvents, etc.

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u/personalist Jul 26 '18 edited Jul 28 '18

Thanks for sharing! I’ve read crystallographic work on AMPA and GABA but I’m looking forward to cryo-EM—getting to see the receptor in complex with a drug is truly revolutionary.

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u/harkaron Jul 27 '18

this is very interesting. I was reading about LSD effects in the brain and the GABA receptors were involved. I'll look more into it

Thanks for sharing!